Application of Nanoporous Carbon Balls on Chromatographic Columns

Chromatographic fillers are the core materials for achieving component separation in chromatography, which directly affects the separation efficiency of chromatography and the accuracy of detection data. Chromatographic fillers can be divided into three categories based on their matrix materials: inorganic matrix fillers, organic matrix fillers, and composite materials. Among them, silicone matrix chromatography packing is currently the most widely used inorganic packing due to its advantages of high mechanical strength, high column efficiency, controllable packing particle size and pore size, etc. However, it has defects such as a narrow pH value application range (2-8) and residual silicon hydroxyl groups on the surface, which limit its further application. Carbon molecular sieves have the advantages of large specific surface area and controllable pore size. Due to the difficulty in forming spherical shapes, it is difficult to evenly pack the filler, resulting in disadvantages such as uneven linear flow rate, lack of concentration in elution, and poor repeatability.

For this, we developed Microporous carbon spheres with diameter 50-1000 μM (adjustable particle size), specific surface area 700-1000m2/g and aperture distribution 0.2-1.7nm, the advantages of them are good sphericity, uniform size, large specific surface area, acid and alkali resistance, and no residual functional groups on the surface.

Overall, nano porous carbon spheres have the advantages of monodisperse silica gel and carbon molecular sieve, and have good application prospects in chromatographic fillers.